GET-Evidence

= Genotype + Environment = Trait (GET) Evidence Database =

The '''GET Evidence''' project was started by Abraham Rosenbaum, Joe Thakuria, Xiaodi Wu and Alexander Wait Zaranek to help the [http://personalgenomes.org Personal Genome Project], the clinical genetics community, and, the general public interpret individual genomes. The database is closely integrated with [wiki:Trait-o-matic].

You can find the PGP production server at: * http://evidence.personalgenomes.org

A development sandbox can be found at: * http://evidence-dev.personalgenomes.org

Many contributors helped make '''GET Evidence''' possible. You can find specific contributions at: * http://evidence.personalgenomes.org/editors

Please help the project by editing the database or making suggestions on the wiki!

To Do
[wiki:GET-Evidence/23andWe] Field Descriptions and Definitions * Short Summary: Each of these fields is a sliding scale of 0-5 where 0 represents no evidence and 5 strong evidence that the Impact is correct.
a. Computational: Average of predictions generated by SIFT, !PolyPhen and NBLOSUM.
a. Molecular and Cellular: Results of enzyme extracts, cell lines and animal models.
a. Clinical
i. Population: Odds Ratio
i. Family: LOD score.
i. Outcomes: The quality of studies investigating the effectiveness of action based on the described impact of this mutation. * Impact
a. Pathogenic
a. Putative Pathogenic
a. Putative Benign
a. Benign
a. Putative Protective
a. Protective
a. Other
a. Unknown * Inheritance Pattern
a. Dominant
a. Recessive
a. Other
a. Unknown * Summary of published research, and additional commentary * Allele Frequency * Publications * Genomes * Other External References
a. dbSNP
a. Genetests
a. Web Search Results * Edit History Suggestions

• your suggestion here.