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Revision 10 (Jason Bobe, 02/01/2010 02:32 PM) → Revision 11/88 (Jason Bobe, 02/01/2010 02:35 PM)
= Genotype + Environment = Trait (GET) Evidence Database = The '''GET Evidence''' project was started by Abraham Rosenbaum, Joe Thakuria, Xiaodi Wu and Alexander Wait Zaranek to help the [http://personalgenomes.org Personal Genome Project], the clinical genetics community, and, the general public interpret individual genomes. The database is closely integrated with [wiki:Trait-o-matic]. You can find the PGP production server at: * http://evidence.personalgenomes.org A development sandbox can be found at: * http://evidence-dev.personalgenomes.org Many contributors helped make '''GET Evidence''' possible. You can find specific contributions at: * http://evidence.personalgenomes.org/editors Please help the project by editing the database or making suggestions on the wiki! == To Do == [wiki:GET-Evidence/23andWe] == Field Descriptions and Definitions == * Short Summary: Each of these fields is a sliding scale of 0-5 where 0 represents no evidence and 5 strong evidence that the Impact is correct. a. Computational: Average of predictions generated by SIFT, !PolyPhen and NBLOSUM. a. Molecular and Cellular: Results of enzyme extracts, cell lines and animal models. a. Clinical i. Population: Odds Ratio i. Family: LOD score. i. Outcomes: The quality of studies investigating the effectiveness of action based on the described impact of this mutation given a specific phenotype/family history mutation. * Impact a. Pathogenic: Pathogenic a. Putative Pathogenic a. Putative Benign a. Benign a. Putative Protective a. Protective a. Other a. Unknown * Inheritance Pattern a. Dominant a. Recessive a. Other a. Unknown * Summary of published research, and additional commentary * Allele Frequency * Publications * Genomes * Other External References a. dbSNP a. Genetests a. Web Search Results * Edit History == Suggestions == * your suggestion here.