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Revision 11 (Jason Bobe, 02/01/2010 02:35 PM) → Revision 12/88 (Jason Bobe, 02/01/2010 02:43 PM)
= Genotype + Environment = Trait (GET) Evidence Database =
The '''GET Evidence''' project was started by Abraham Rosenbaum, Joe Thakuria, Xiaodi Wu and Alexander Wait Zaranek to help the [http://personalgenomes.org Personal Genome Project], the clinical genetics community, and, the general public interpret individual genomes. The database is closely integrated with [wiki:Trait-o-matic].
You can find the PGP production server at:
* http://evidence.personalgenomes.org
A development sandbox can be found at:
* http://evidence-dev.personalgenomes.org
Many contributors helped make '''GET Evidence''' possible. You can find specific contributions at:
* http://evidence.personalgenomes.org/editors
Please help the project by editing the database or making suggestions on the wiki!
== To Do ==
[wiki:GET-Evidence/23andWe]
== Field Descriptions and Definitions ==
* Short Summary: Each of these fields is a sliding scale of 0-5 where 0 represents no evidence and 5 strong evidence that the Impact is correct.
a. Computational: Average of predictions generated by SIFT, !PolyPhen and NBLOSUM.
a. Molecular and Cellular: Results of enzyme extracts, cell lines and animal models.
a. Clinical
i. Population: Odds Ratio
i. Family: LOD score.
i. Outcomes: The quality of studies investigating the effectiveness of action based on the described impact of this mutation given a specific phenotype/family history
* Impact
a. Pathogenic:
a. Putative Pathogenic
a. Putative Benign
a. Benign
a. Putative Protective
a. Protective
a. Other
a. Unknown
* Inheritance Pattern
a. Dominant
a. Recessive
a. Other
a. Unknown
* Summary of published research, and additional commentary
* Allele Frequency
* Publications
* Genomes
* Other External References: These are automatically generated References
a. dbSNP: The link to the dbSNP entry for this nucleotide position (for this nucleotide change?)
a. Genetests: Link to all clinical laboratories performing diagnostic tests on this gene and the list of diseases that the labs are looking for. Genetests
a. Web Search Results: A web search for this exact variant using the Yahoo search engine Results
* Edit History
== Suggestions ==
* your suggestion here.